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Welcome to Prevention Research Consortium Corp

ABOUT US

Prevention Research Consortium Corp is a non-profit dedicated to reducing the global burden of dementia.


Our vision is to combine genomic and fluid biomarker analysis to build a risk-assessment model that accurately predicts the incidence and stage of mild cognitive impairment from multiple causes, particularly late-onset Alzheimer's disease (LOAD). The use of an advanced model for comorbidity and all-cause adult dementia prediction is central to our multi-site, international study plan.


We aim to deliver clinical validation of fluid biomarker models that identify high-risk pre-LOAD individuals 5–10 years before plasma brain-derived pTau217 signals AD predementia—well before cognitive symptoms emerge. Findings from our international, multi-site study could transform early intervention strategies in dementia care.


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Who we are

 Prevention Research Consortium Corp is a non-profit organization focused on reducing the global burden of dementia.  Our members include an interdisciplinary team of Genomics Experts, Proteomic Specialists, Neurologists, Psychiatrists, Primary Care Providers, Caregivers, Dementia Patients, Digital Technologists, Bioinformaticians,  AI Specialists, and Generalists.


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Our Mission

  Develop and validate scalable biomarker tools for the early prediction and staging of mild cognitive impairment ( The precursor to All Cause Dementia) . We leverage proteomic, genomic, and AI-driven approaches to enable accurate, accessible early detection of  mixed pathology cases.

Building on this foundation, we aim to promote unbiased and independently validated technologies to improve detection and prevention of all diseases. Our goal is to help drive the shift from precision medicine to precision health—moving from reactive care to proactive, individualized prevention.

By  integrating  genomic, exposomic ( pollutants, diet + microbiome), metabolomic, proteomic, immunome, and RNA technologies into rigorous clinical research, we seek to deliver evidence-based strategies that improve outcomes, personalize care, and reduce the global burden of dementia and other diseases.


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External link opens in new tab or windowOur Approach

We evaluate the sensitivity and specificity of biomarker tools with a focus on early prediction or diagnosis of Late-Onset Alzheimer's Disease (LOAD). While our current efforts center on Alzheimer's, our General Proteogenomic and Exposome Approach is broadly applicable to advancing precision healthcare across a wide range of conditions.  Our External link opens in new tab or windowLOAD Biology Model is being evaluated in a prospective  clinical study  to assess  tools  that predict and subclassify Mild Cognitive Impairment .   We plan to help evolve mathematical models and data collection tools to meet the challenges of predictive analytics.
Leading Members

External link opens in new tab or windowFoster Carr MD - founder, CEO,  and PI

External link opens in new tab or windowMahdi Mogri PhD

External link opens in new tab or windowCarlos Cruchaga PhD

External link opens in new tab or windowCarolina Soares PhD, PI

External link opens in new tab or windowKatherine Toups MD, PI

External link opens in new tab or windowRawan Tarawneh MD, PI

External link opens in new tab or windowAndres D Klein PhD

Members

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Scott Burwell PhD

Steve Charlap MD

Thomas Karikari PhD

Gary Strobel MS

External link opens in new tab or windowLeonardo Lado MD

Christopher Wheeler PhD

Sophie Grapentine PhD

Lyla Anderson MD, PhD

Chris Barry PhD

Gautum Wali PhD

Aren Giske MD

Andres Servea PhD

Lasse Folkersen PhD

Breno Diniz PhD

Qiang Liu PhD

Varun Dwaraka PhD

Ryan Smith PhD

NEWS

External link opens in new tab or windowAdvancing a systems-level understanding of neurodegeneration: the BrightFocus Alzheimer’s disease research portfolio | Molecular Neurodegeneration | Springer Nature Link August 21 2026


External link opens in new tab or windowA plasma‐based protein signature combining NPTXR, ACHE, and p‐tau217 predicts progression to symptomatic Alzheimer's disease August 14 2026


External link opens in new tab or windowRegional astrocyte dysregulation and altered glymphatic‐related markers in Alzheimer's disease frontal cortex - August 14 2026


External link opens in new tab or windowProteomic signatures of protected APOE ε4 carriers reveal causal pathways associated with delayed Alzheimer's disease onset - Le Guen - 2026 - Alzheimer's & Dementia - Wiley Online Library August 13 2026


External link opens in new tab or windowVulnerability of locus coeruleus connections to aging and Alzheimer's disease - Zufiria‐Gerbolés - August 12 2026


External link opens in new tab or windowPrediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers | Science Advances August 12 2026


External link opens in new tab or windowToward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments | npj Dementia August 12 2026


External link opens in new tab or windowGlycation at the Gate: A Brain Endothelial Glycocalyx Model and Therapeutic Roadmap for Alzheimer's Disease August 10 2026


External link opens in new tab or windowNew human genome benchmark captures both parental copies with near-perfect accuracy August 10 2026


External link opens in new tab or windowPlasma Biomarkers for Neocortical Tau Burden | Radiology | JAMA Neurology | JAMA Network (p-tau217, NPTXR, GDNF, KLK6, IL-13, Aβ40, and SFRP1) August 10 2026


External link opens in new tab or windowEvaluating digital cognitive tests for clinical use in Alzheimer's disease: A novel framework and scoping review - Hampel - 2026 - Alzheimer's & Dementia - Wiley Online Library  July 31 2026


External link opens in new tab or windowCytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease | bioRxiv July 28 2026


External link opens in new tab or windowLongitudinal plasma proteomics predict phenoconversion to clinically manifest ALS | Nature Medicine July 27 2026


External link opens in new tab or windowMitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease | Nature Neuroscience July 26 2026


External link opens in new tab or windowCross‐ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts - Okorie - 2026 - Alzheimer's & Dementia - Wiley Online Library July 26 2026


External link opens in new tab or windowEpigenetic and 3D genome reprogramming during the aging of the human hippocampus | Science July 23 2026


External link opens in new tab or windowAPOE4 disrupts the central dogma by arresting neuronal proteome dynamics | bioRxiv July 22 2026


External link opens in new tab or windowRestored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging | Science July 16 2026


External link opens in new tab or windowCell-type signatures of Alzheimer's disease shared across population groups | Nature July 15 2026


External link opens in new tab or windowPredicting Risk of Cognitive Impairment with Alzheimer's Disease Blood Biomarkers July 14 2026


External link opens in new tab or windowCIT-Lasso: a scalable approach beyond guilty by association for identifying causal variants from genome-wide summary statistics July 3 2026


External link opens in new tab or windowMultiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer's disease | bioRxiv July 2 2026


External link opens in new tab or windowAlzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA | Science Translational Medicine July 1 2026


External link opens in new tab or windowBlood-based circular RNAs for early diagnosis of Alzheimer’s disease | Nature Medicine July 1 2026


External link opens in new tab or windowSECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer's disease | Nature Communications June 22 2026


External link opens in new tab or windowA new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms | Molecular Psychiatry June 22 2026


External link opens in new tab or windowAPOE4 risk‐modifying genes and drug targets in Alzheimer's disease through cell‐type‐specific genomic analyses June 22 2026


External link opens in new tab or windowUnraveling Aberrant Metabolic Patterns in Alzheimer's Disease Subtypes: From Perturbed Metabolic Pathways to Candidate Drug Targets | Molecular Neurobiology | Springer Nature Link June 18 2026


External link opens in new tab or windowA blood test for dementia may tell you if you have more than one type June 16 2026


External link opens in new tab or windowPlasma proteomic signatures of cellular aging predict human disease | Nature Medicine  June 14 2026


External link opens in new tab or windowGWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease | Nature Communications June 4 2026


External link opens in new tab or windowPrimary prevention of Alzheimer disease in dominantly inherited Alzheimer network: a platform trial design | npj Dementia June 1 2026


External link opens in new tab or windowAlzheimer's disease - ScienceDirect May 30 2026


External link opens in new tab or windowNeuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner | Nature Neuroscience May 29 2026


External link opens in new tab or windowReduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology | Nature Aging May 14 2026


External link opens in new tab or windowLinking the exposome to the brain–behaviour phenotype | Nature Reviews Neuroscience May 14 2026


External link opens in new tab or windowCell-type-specific APOE4 cascade across the Alzheimer's disease continuum: Neuron May 14 2026


External link opens in new tab or windowBcnPit - Ace Alzheimer Center Barcelona May 13-15 2026


External link opens in new tab or windowProteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease | Nature Aging May 15 2026 Preprinted Aug 2025


External link opens in new tab or windowAssociation of Rare APOE Missense Variants R189C and W276C With Risk of Alzheimer Disease | medRxiv May 12 2026


External link opens in new tab or windowEarly syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease | Alzheimer's Research & Therapy | Springer Nature Link May 7 2026


External link opens in new tab or windowGPND‐AI NULISA: A 15‐Protein AI classifier for diagnosis and co‐pathology profiling across neurodegenerative diseases - Xu - 2026 - Alzheimer's & Dementia - Wiley Online Library April 28 2026


External link opens in new tab or windowNeurexins, Ephrin receptors, and N-cadherin signaling as emerging mechanisms in synaptic dysfunction and neurodegenerative diseases April 17 2026


External link opens in new tab or windowEarly peripheral immune signaling precedes tau elevation and blood–brain barrier disruption in Alzheimer's disease | bioRxiv April 4 2026


External link opens in new tab or windowLarge-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases | Wu Tsai Neurosciences Institute March 31 2026


External link opens in new tab or windowA deep joint-learning proteomics model for diagnosis of six conditions associated with dementia | Nature Medicine March 31 2026


External link opens in new tab or windowPrevention Research Consortium obtains IRB approval for a Predict Predementia Longitudinal observation study of ApoE4 Carriers. March 26 2026


External link opens in new tab or windowPopulation-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer’s disease and Parkinson’s disease | medRxiv March 4 2026


External link opens in new tab or windowIdentification of plasma inflammatory biomarkers for Alzheimer's disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype Feb 15 2026


External link opens in new tab or windowAPOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease - Li - 2026 - Advanced Science - Wiley Online Library Feb 5 2026


External link opens in new tab or windowModelling the temporal evolution of plasma p-tau217, amyloid PET, tau PET and cognition | Brain | Oxford Academic Feb 25 2026


External link opens in new tab or windowCures Alzheimer's Fund Grants Award for Proteogenomic Model that predicts Late onset Alzheimer's Disease. Feb 2026


External link opens in new tab or windowLarge‐scale proteomics analysis of Alzheimer's Disease plasma blood reveals sex and APOE specific signatures - PMC Jan 12 2026


External link opens in new tab or windowIntegrating large-scale serum metabolomics and APOE ε4 genotype status for the non-invasive detection of Alzheimer's disease in the ADNI cohort - PubMed Jan 2026


External link opens in new tab or windowThomassen JQ, Leonard H, Ulms B, et al. APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimer's disease. medRxiv. Preprint Published online December 19, 2025 December 19 2025


External link opens in new tab or windowStaging Alzheimer's disease through amyloid and tau PET | Brain | Oxford Academic Sept 25 2025


External link opens in new tab or windowThe China Alzheimer Report 2025 - PubMed August 7 2025


External link opens in new tab or windowProtein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma Classification July 10 2025


External link opens in new tab or windowA cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease | Nature Medicine March 31 2025


External link opens in new tab or windowThe Dementia SomaSignal Test (dSST): A plasma proteomic predictor of 20-year dementia risk - PubMed Feb 12 2025


External link opens in new tab or windowNon-coding RNAs in the pathogenesis of Alzheimer’s disease: β-amyloid aggregation, Tau phosphorylation and neuroinflammation | Molecular Biology Reports | Springer Nature Link January 31 2025


External link opens in new tab or windowPolygenic burden of short tandem repeat expansions promotes risk for Alzheimer's disease - PubMed Jan 2025


External link opens in new tab or windowIdentifying proteomic prognostic markers for Alzheimer's disease with survival machine learning: The Framingham Heart Study - PMC Jan 21 2025


External link opens in new tab or windowNoncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance | Bentham Science April 9 2024


External link opens in new tab or windowRevised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup Feb 27 2024


External link opens in new tab or windowPlasma proteomic profiles predict future dementia in healthy adults | Nature Aging Feb 12 2024 (summary and comments - External link opens in new tab or windownature_aging_24b.pdf)


External link opens in new tab or windowAlzheimer's disease‐associated P460L variant of EphA1 dysregulates receptor activity and blood‐brain barrier function - PMC January 7 2024


External link opens in new tab or windowRoad map for clinicians to develop and evaluate AI predictive models to inform clinical decision-making - PMC August 2023


External link opens in new tab or windowAging gene signature of IL-7 receptor alpha low effector memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer's disease April 4 2023


External link opens in new tab or windowA retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease | GeroScience | Springer Nature Link May 19 2022


External link opens in new tab or windowImmune system and blood-brain barrier-wide biomarker analyses provide causal evidence for autoimmunity in dementia February 16 2021


External link opens in new tab or windowCompromised Behavior and Gamma Power During Working Memory in Cognitively Healthy Individuals With Abnormal CSF Amyloid/Tau  Oct 14 2020


External link opens in new tab or windowFrontiers | Circular RNAs: Novel Regulators of Neuronal Development August 25 2016


External link opens in new tab or windowDevelopment of Screening Guidelines and Clinical Criteria for Predementia Alzheimer's Disease: The DESCRIPA Study - PMC June 2 2008




Our Working Project Plan


Tools and Services



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Multi modal Assessment Tools

rin.  - We identify and validate scalable tools for detecting high risk individuals for progression to  early cognitive change . These tools include :

  • Protein biomarker based disease classification and progression prediction models - See our News Section for the models being evaluated.
  • Nucleomics (RNA and DNA) based prognostic and diagnostic biomarkers -External link opens in new tab or windowcircular RNA profiles, External link opens in new tab or windowlncRNA , External link opens in new tab or windowSECmeres  (protein, lipid, RNA), brain derived EV miRNA profiles, External link opens in new tab or windowTRPC6 mRNA levels in PBMC, and External link opens in new tab or windowMethylated DNA from dead brain cells .
  • Speech biomarker tests and digital cognitive assessments that can be deployed efficiently in diverse clinical and community settings.
  • Genomic variant analysis pipelines /AI Models including PRS and External link opens in new tab or windowSTR risk scoring.
  • Long Read vs Short Read Whole Genome Sequencing with Imputation to improve variant detection accuracy, phasing, and clinical interpretation across diverse populations.
  • AI Analyzers of Longitudinal Medical Records
  • Metabolo-Glyco-Lipidomics based biomarkers ( sphingomyelin/ceramide/phospholipid/cholesterol ratios )
  • Wearable device data capture, transmission, and AI analysis
  • Retinal Diagnostic Imagers and Analysis software
  • Invoked-Evoked EEG biomarkers
  • AI Software for analysis of  Radiological Imaging Scans

 Our goal is to improve   pre-dementia prediction , staging,  and treatment guidelines.  We need your help in raising funds to support our  External link opens in new tab or windowClinicaltrials.gov listed study, (External link opens in new tab or windowAssessing Tools that Predict and Stage Mild Cognitive Impairment). Tax deductible contributions will help us to expand from a small number of pilot subjects to a larger international  cohort with high protein, circRNA, genomic, medical-family history, environmental, and lifestyle risks  for LOAD and other Dementias. Review our  Working Project Plan to see where we are  in the process of generating non-biased data insights that can improve early detection, prevention, and personalized care for All Dementias .


You are eligibility to enroll in our  longitudinal clinical study  if you are  over 55 years  old , carry at least 1 ApoeE4 gene, and pass anExternal link opens in new tab or window online cognitive impairment screening test  Please call Dr. Carr at  877  271 6078 after taking the online External link opens in new tab or windowsaturn-test , provide your test number and then continue the eligibility screening process.

You may also start the process  collaborating by eExternal link opens in new tab or windownrolling now as a member , patient, subject, provider, and/or vendor of our  prevention services.


 Benefits of consortium registration include  networking in special interest groups, access to  prognostic prediction and staging tools, risk questionnaires, toxicology/lab ordering services, disease model repositories, storage of your wearable/imaging/ fluid biomarker data, and collaboration tools.


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Members can join  special interest working groups on :

  1. External link opens in new tab or windowBiological Models of External link opens in new tab or windowDementias including External link opens in new tab or windowAD
  2. Biofluid External link opens in new tab or windowBiomarkers : External link opens in new tab or windowsaliva , plasma, serum, tears, urine and ISF .
  3. Predictive Analytics using External link opens in new tab or windowWhole Genome Sequencing, External link opens in new tab or windowPolygenic Risk Scoring , External link opens in new tab or windowSTR risk scoring,  External link opens in new tab or windowProteomics  ,Nucleomics, Metabolomics-Lipidomics, Microbiomics and/or  misfolded/denatured/aggregated/seeding protein assays.
  4. Thymic involution, decreased IL7,  Increased senescent Memory Effectors  Cells,  Pathogenic Brain parenchymal External link opens in new tab or windowCD8 T cells and Neuro-Glial External link opens in new tab or windowauto antibodies from dysregulated Plasma B cells as biomarker predictors of  preclinical AD
  5. Cognitive  External link opens in new tab or windowFunctional  Assessments

  6. External link opens in new tab or windowEEG, MEG, Neuro(MRI,PET, CT) and Retinal IExternal link opens in new tab or windowmaging 

  7. External link opens in new tab or windowClinical Guidelines,  Trial Recruitment , External link opens in new tab or windowRegulatory & Ethics

  8. External link opens in new tab or windowData , IT InfrastrExternal link opens in new tab or windowucture, External link opens in new tab or windowAI/Data Fusion & Analytics

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Help spread awareness about the External link opens in new tab or windowPredict Predementia Clinical Study by sharing it on External link opens in new tab or windowLinkedIn, External link opens in new tab or windowFacebook, External link opens in new tab or windowBluesky, External link opens in new tab or windowX, and by word of mouth.



Prevention Research Consortium Corp
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